Impact of gene polymorphism of glutathione S-transferase and ghrelin as a risk factor in Egyptian women with gestational diabetes mellitus

Abstract Background Gestational diabetes mellitus is the most common metabolic dysfunction that arises during pregnancy. GDM can lead to serious health complications for both mother pregnancy and after delivery of baby. Additionally, mother–offspring suffers from abnormalities in metabolism. The study aimed investigate glutathione S?transferase P1 ghrelin genetic variants pregnant women diagnosed with gestational using a tetra-primer amplification refractory mutation system. Results This demonstrated frequencies genotypes were GSTP1-AG (87.1%) GHRL-GG (100%). revealed no significant differences frequency either genotype or allele GSTP1 between healthy women. Conclusions may be first designed demonstrate there association (rs1695) (rs696217) development Egyptian